Can I give double the dose once daily instead of giving the supplement twice daily?

While it would be safe to give your pet a double dose, we do not recommend dosing this way. The supplements are required to be given in two doses because of the time that they remain active in the body. If you give 1ml of supplement at 8am, by around 8pm the level of supplement has almost completely dropped off, even though it was double the dose. When giving the supplement twice daily, you are maintaining a constant level of the supplement in the system, which is what is required for the efficacy. With once per day dosing the supplements may significantly lose effectiveness.